Cyberbone sp. z o.o.

The goal of the project is to implement and develop technologies for individualized resorbable anatomical spatial structures that will be purpose-designed medical bone implants for use in neurosurgical calf and facial skeletal reconstruction, including in the youngest pediatric patients. Advances in materials used in regenerative medicine, and in particular in bone loss replacement, are leaving technologies for shaping such materials behind. This is particularly evident in the case of bioresorbable materials. It is necessary to preserve their physical properties, i.e. porosity. Commercially available equivalents in terms of expected anatomical location and clinical use are not only not made of bioresorbable materials (they are most often made of metal or non-biodegradable plastics), but are also supplied to surgeons in standardized shapes. Their adjustment to the bone loss during surgery requires additional skill on the part of the surgeon, prolongs the surgery time (also entailing the risk of additional intraoperative complications), and carries a high risk of treatment error. Some correction procedures include the possibility of multiple sterilization processes (after the initial correction performed by the surgeon), which maximizes the risk of microbial contamination and the risk of complications related to bacterial endotoxins. Aesthetics and restoration of the natural shape of the skull should also be considered, which is associated with patient well-being and aesthetic comfort. The solution is the technology of highly aesthetic implants matched to anatomical features, which are made of biodegradable copolymer of polylactide (PLA) or its derivatives. This polymer is characterized by gradual biodegradation and is metabolically absorbed by the body. Under intraoperative and postoperative conditions, PLA exhibits full biocompatibility. It is possible to modify the resorption time of the implanted material so that the process of bone remodeling can take place during the resorption of the implant. The solution makes it possible to repair the defect/damage to the anatomical structure of the bone during the surgery and restore the anatomically normal bone structure with simultaneous absorption of the implant itself. The products reflect the anatomical shape of the regenerated areas and will be tailored to meet the needs of calvarial and facial skeletal reconstruction. Our solutions enable the fabrication of spatial structures for biomedical engineering applications, such as personalized bone loss treatment implants custom-made by a surgeon for a specific pediatric patient, a product innovation. The developed technology is being used to provide a perfect fit based on the processing of available CT and MRI scans of a portion of bone tissue or cellular scaffolding, which will then be reconstructed using a 3D bioplotter, extruder, injection molding machine and polymer solution casting in a mold made of biocompatible materials. The low cost of the implant is also an important feature of the technology - crucial for subsequent successful implementation and widespread availability. So will the success of further R&D to adapt the solution to, for example, tooth reconstruction and regenerative medicine using stem cells to maximize the technology's potential. 
The implementation strategy involves creating a “bridge” between the doctor and manufacturers of custom medical devices.
Currently, there are a number of companies on the market offering similar comprehensive dental technology. There are also individual players offering similar technology in the field of orthopedics. The difference, however, is the project's focus on the use of materials with advanced and directional biodegradability options combined with filling identified gaps related to medical device functionality and safety. The synergy of IT modeling tools and medical imaging processing software has also not been applied in such detail before.