ATLANGRAM

Atlangram is specialized in efficacy optimisation and evaluation of antibacterial agents. Our project consists of development of a Drug Delivery System (DDS), composed of a gel containing Lipid Nano-Capsules (LNCs). This DDS could be a solution to improve PK/PD parameters of antibiotics to confer them well-established efficacy and minimized side effects.

That is what we have demonstrated by applying this technology to Daptomycin (a marketed and genericized antibiotic which exists only by intravenous route): Daptogel.

Daptogel results are very encouraging in terms of entrapment efficiency (100%) and preclinical efficacy in an Osteomyelitis rabbit reference model. Briefly, the in vitro (MICs, MBCs, Kill-curves) and in vivo studies (ED 50%, Efficacy, Pharmacokinetic, Safety) have shown excellent activity of Daptogel against Staphylococcus  aureus (MRSA) with an eradication up to 14 days post-treatment of the bacteria in bone and bone marrow compartments with a single dose. Daptogel shows significant superiority to intravenously administered antibiotics (linezolid, daptomycin, ceftarolin and vancomycin).