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KleinKlein, GmbH
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KleinKlein, GmbH
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Allemand

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SET solution for chronic pain. 100 million EU sufferers, €300 billion, Age related. Current solutions do not look at data, biomarkers, or take into consideration the individual differences between patients. With real data from large groups of patients, for the first time, cluster patients into biopsychosocial subgroups. We can characterize the patient's autonomic nervous system, which is depreciated in chronic pain patients, and use it to fight chronic pain. With the therapy, which...

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SET solution for chronic pain. 100 million EU sufferers, €300 billion, Age related. Current solutions do not look at data, biomarkers, or take into consideration the individual differences between patients. With real data from large groups of patients, for the first time, cluster patients into biopsychosocial subgroups. We can characterize the patient's autonomic nervous system, which is depreciated in chronic pain patients, and use it to fight chronic pain. With the therapy, which combines cardiac gated electrical stimulation to the finger plus operant behavioral therapy, we attack the underlying psychological and biophysical causes for the pain. The SET device allows us to do this efficiently. Using ICT data, we are able to make real progress on this large social problem.  With the data and a biomarker (BRS-baroreflex sensitivity) we can adjust the protocol during treatment if it is not working. SET was tested at the University of Marburg with 120 patients that included 2 sham protocols. Of the non-control participants, 100% of fibromyalgia patients became pain-free for six months, and 82% at the 12-month follow-up. The data, which includes all the EKG, BRS, SCL, EMG, blood pressure the patients' initial interview, and progress data from the E-learning system, will be uploaded to a MySQL database hosted on a medical grade cloud server.  A real solution for a debilitating social problem which involves ICT, big data, and job creation.

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Certifications

Seal of Excellence
The Seal of Excellence is a quality label awarded to project proposals submitted to Horizon 2020 which succeeded a highly competitive evaluation process by independent experts, but did not received funding due to budget limits. This quality label is a guarantee for investors to find high standard project proposals from European SMEs with growth potential.
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Our history

Start in Discovery 2010

  • Discovery 2010

    SET protocol, which increases BRS and makes patients pain-free was discovered by Dr. Thieme (UNC).

  • IP (2011-16)

    UNC filed a patent in 2014 which was issued in 2016.

  • Concept/Testing (2013-16)

    SET was tested at the University of Marburg with 120 patients that included 2 sham protocols.

  • Market Research (2015-16)

    The approachable market for chronic pain was defined

  • Prototype Iterations (2014-17)

    The SET device, which provides the electrical stimulation to the finger and defibrillates pain.

to be continued ...