ISQUAEMIA BIOTECH, S.L.

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About your organization

Isquaemia Biotech is a Biotech Company focused on development of a new line of drugs and compounds to treat the Central Nervous System (CNS) pathologies, such as Acute Ischemic Stroke (AIS).

Isquaemia is developing a new neuroprotective drug for the treatment of AIS that seeks to improve the efficacy of current treatments, the therapeutic window and meet the clinical needs not covered. The drug acts in a specific area of the brain and it is able to reduce and even reverse the neurological damage caused.

The new drug is a hybrid steroid-nitrone, with neuroprotective and neurorepairer characteristics, that can reduce and reverse the neurological damage caused after the stroke.

The drug under development is in the preclinical phase, where tests on toxicology and metabolism have already been successfully overcome in animal models (mice and rats). To date, the results obtained with the candidate drugs of Isquaemia are totally positive. If we compare the results of our candidates and those obtained with other drugs on the market, we find that Isquaemia's products outperform them in terms of neuroprotection, permeability, neurorepair and improvement of clinical conditions.

Currently, the Isquaemia's drug is starting the regulatory preclinical phase.

The new Isquaemia drug will have a good position in the current market due to the absence of competitors (therapeutic alternatives) in neuroprotection.

News

ENRIQUE SAINZ (ADVISOR, ISQUAEMIA BIOTECH, S.L. )

Published 4 years ago

Isquaemia Biotech closer to the clinical phase of neuroprotective drugs for stroke

Isquaemia Biotech, a company participated by Canaan Research and Investment, is investigating the neuroprotective properties of a battery of molecules for the treatment of ischemic stroke.

Isquaemia works in collaboration with prestigious researchers from the Instituto de Química Orgánica of CSIC, the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), the Instituto de Investigación Vall d’Hebron and the Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI).

Preliminary results obtained to date have demonstrated neuroprotective properties (significantly reducing neurological damage) that allow improving the effectiveness of current treatments, which are restricted to restore blood flow or reperfusion (with pharmacological fibrinolysis or mechanical recanalization).

These results have been published in renowned scientific journals in the sector. In 2019, studies that demonstrated the antioxidant and neuroprotective effects of some developing molecules by Isquaemia Biotech for the treatment of ischemic stroke were published in the Journal of Medicinal Chemistry (J. Med. Chem. 2019; 62:2184−2201) and in ACS Chemical Neuroscience Neuroscience (ACS Chem Neurosci. 2019; 10:2703-2706).